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MilliporeSigma™ CIP4, Mouse, Unlabeled, Clone: 8F10.1,

Catalog No. MABN1555MI Shop All MilliporeSigma Products
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Quantity:
100 μg
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
MABN1555MI 100 μg Unconjugated
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Catalog No. MABN1555MI Supplier MilliporeSigma™ Supplier No. MABN1555

Description

Mouse Monoclonal Antibody

Cdc42-interacting protein 4 (UniProt Q15642; also known as hSTP, CIP4, Protein Felic, Salt tolerant protein, Thyroid receptor-interacting protein 10, TR-interacting protein 10, TRIP-10) is encoded by the TRIP10 (also known as CIP4, STOT, STP) gene (Gene ID 9322) in human. Cdc42-interacting protein 4 (CIP4) is a member of the F-BAR family of proteins. These proteins contain a hydrophobic N-terminal, alpha-helical region that is related to the Bin Amphiphysin Rvs (BAR) protein family. The F-BAR domain binds the phospholipid membrane with its concave surface. CIP4 contains an SH3 domain that has been reported to play a role in endocytosis; an REM (Hr1) repeat, and an FCH domain, which facilitates in microtubule binding. CIP4 plays several other important roles in cells. It is an essential component of insulin signaling for GLUT4 translocation to the plasma membrane and is also required during endocytosis for the orchestration of membrane tabulation with the remodeling of the actin cytoskeleton. It is shown to binds to lipids such as phosphatidylinositol 4, 5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CIP4
Applications Western Blot
Classification Monoclonal
Clone 8F10.1
Concentration Please refer to lot specific datasheet.
Conjugate Unconjugated
Formulation Purified mouse IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene TRIP10, CIP4, STOT, STP
Gene Accession No. Q15642
Host Species Mouse
Immunogen GST-tagged recombinant human CIP4 fragment corresponding to a region within the F-BAR domain.
Purification Method Protein G Purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Neuroscience
Primary or Secondary Primary
Gene ID (Entrez) NP_001275891
Test Specificity Clone 8F10.1 targeted region is present in all five human and all four murine spliced isoforms reported by UniProt (Q15642 and Q8CJ53).
Target Species Human
Content And Storage Stable for 1 year at 2°-8°C from date of receipt.
Form Purified
Isotype IgG1 κ
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For Research Use Only. Not for use in diagnostic procedures.

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