Invitrogen™ CIS Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA579048

Catalog No. PIPA579048

Description

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: human MCF-7 whole cell, human Hela whole cell, human COLO320 whole cell, human CACO-2 whole cell. IHC: Human Lung Cancer Tissue, Rat Kidney Tissue. ICC/IF: U2OS cells.

CIS contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: CIS
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CISH
• Gene Alias: AI385595; BACTS2; Cis; CIS1; CIS-1; Cish; CISH_tv2; cytokine inducible SH2 containing protein; cytokine inducible SH2 protein; cytokine inducible SH2-containing protein; cytokine inducible SH2-containing protein 1; cytokine-inducible inhibitor of signaling type 1B; cytokine-inducible SH2 protein; cytokine-inducible SH2-containing protein; F17; F23; G18; Protein G18; similar to Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS) (G18); SOCS; Suppressor of cytokine signaling
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1154, 12700, 83681
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 500 μg/mL
• Formulation: PBS with 5mg BSA and 0.05mg sodium azide, 0.05mg thimerosal
• Gene Accession No.: O70512, Q62225, Q9NSE2
• Gene Symbols: CISH
• Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human CISH (241-258aa LPLPRRMADYLRQYPFQL).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG