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Invitrogen™ CIS Polyclonal Antibody
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Catalog No. PIPA579048
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100 μg
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PIPA579048 100 μg
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Catalog No. PIPA579048 Supplier Invitrogen™ Supplier No. PA579048
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Description

Rabbit Polyclonal Antibody

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: human MCF-7 whole cell, human Hela whole cell, human COLO320 whole cell, human CACO-2 whole cell. IHC: Human Lung Cancer Tissue, Rat Kidney Tissue. ICC/IF: U2OS cells.

CIS contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CIS
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 500 μg/mL
Conjugate Unconjugated
Formulation PBS with 5mg BSA and 0.05mg sodium azide, 0.05mg thimerosal
Gene CISH
Gene Accession No. O70512, Q62225, Q9NSE2
Gene Alias AI385595; BACTS2; Cis; CIS1; CIS-1; Cish; CISH_tv2; cytokine inducible SH2 containing protein; cytokine inducible SH2 protein; cytokine inducible SH2-containing protein; cytokine inducible SH2-containing protein 1; cytokine-inducible inhibitor of signaling type 1B; cytokine-inducible SH2 protein; cytokine-inducible SH2-containing protein; F17; F23; G18; Protein G18; similar to Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS) (G18); SOCS; Suppressor of cytokine signaling
Gene Symbols CISH
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence at the C-terminus of human CISH (241-258aa LPLPRRMADYLRQYPFQL).
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1154, 12700, 83681
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Lyophilized
Isotype IgG
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