Invitrogen™ CIS Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5119974

Catalog No. PIPA5119974

Description

Positive Control: PC-12 cell lysate, Hela cell lysate, mouse kidney tissue lysate, mouse testis tissue, rat colon tissue, A431. Subcellular Location: Cytosol, plasma membrane, phosphatidylinositol 3-kinase complex.

CIS contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: CIS
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CISH
• Gene Alias: AI385595; BACTS2; Cis; CIS1; CIS-1; Cish; CISH_tv2; cytokine inducible SH2 containing protein; cytokine inducible SH2 protein; cytokine inducible SH2-containing protein; cytokine inducible SH2-containing protein 1; cytokine-inducible inhibitor of signaling type 1B; cytokine-inducible SH2 protein; cytokine-inducible SH2-containing protein; F17; F23; G18; Protein G18; similar to Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS) (G18); SOCS; Suppressor of cytokine signaling
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1154, 12700, 83681
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: TBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: O70512, Q62225, Q9NSE2
• Gene Symbols: CISH
• Immunogen: Synthetic peptide within human CISH aa 209-258.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG