Invitrogen™ CISD2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5106299

Catalog No. PIPA5106299

Description

Antibody detects endogenous levels of total CISD2.

Defects in the CISD2 (CDGSH iron sulfur domain 2) gene are a cause of the neurodegenerative disorder Wolfram syndrome 2. CISD2 is a zinc finger protein that localizes to the endoplasmic reticulum and mitochondria and binds an iron/sulfur cluster. CISD2 interacts with Bcl-2 and can be displaced by the BH3-only protein BIK and contributes to the regulation of BIK-initiated autophagy. CISD2 deficiency in mice causes mitochondrial breakdown accompanied by autophagic cell death as well as the development of premature aging phenotype.

Specifications

• Antigen: CISD2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CISD2
• Gene Alias: 1500009M05Rik; 1500026J14Rik; 1500031D15Rik; AI848398; B630006A20Rik; BcDNA:RE49709; CDGSH iron sulfur domain 2; CDGSH iron sulfur domain-containing protein 2; CDGSH iron-sulfur domain-containing protein 2; CDGSH iron-sulfur domain-containing protein 2 homolog; Cdgsh2; CG1458; CG1458-PA; cisd2; Cisd2-PA; dkey-162b23.1; Dmel\CG1458; Dmel_CG1458; dWFS2; endoplasmic reticulum intermembrane small protein; ERIS; Miner1; MitoNEET; mitoNEET related 1; mitoNEET-related 1 protein; NAF-1; nervous system overexpressed protein 70; nervous system over-expressed protein 70; Noxp70; Nutrient-deprivation autophagy factor-1; RE49709p; RGD1566242; RH38554p; WFS2; Zcd2; zgc:64148; zgc:64148 protein; zinc finger, CDGSH-type domain 2; zKM0001
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 295457, 493856, 67006
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q8N5K1, Q9CQB5
• Gene Symbols: CISD2
• Immunogen: A synthesized peptide derived from human CISD2(Accession Q8N5K1), corresponding to amino acid residues V83-K133.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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