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CISD2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
SDP

Rabbit Polyclonal Antibody

Supplier:  Proteintech Group Inc 133181AP150UL

Encompass_Preferred

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Catalog No. 50-172-8649


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Description

Description

Defects in the CISD2 (CDGSH iron sulfur domain 2) gene are a cause of the neurodegenerative disorder Wolfram syndrome 2. CISD2 is a zinc finger protein that localizes to the endoplasmic reticulum and mitochondria and binds an iron/sulfur cluster. CISD2 interacts with Bcl-2 and can be displaced by the BH3-only protein BIK and contributes to the regulation of BIK-initiated autophagy. CISD2 deficiency in mice causes mitochondrial breakdown accompanied by autophagic cell death as well as the development of premature aging phenotype.
Specifications

Specifications

CISD2
Polyclonal
Unconjugated
CISD2
CDGSH iron sulfur domain 2, CDGSH2, CISD2, ERIS, Miner1, MitoNEET related 1 protein, NAF 1, WFS2, ZCD2
Rabbit
Antigen Affinity Chromatography
RUO
295457, 493856, 67006
-20°C
Liquid
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation
0.35 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q8N5K1, Q9CQB5
CISD2
CISD2 Fusion Protein Ag4172
150 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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