CK1 epsilon Mouse anti-Human, Clone: OTI5D4, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA526625
DescriptionCasein kinases are a group of ubiquitous Ser/Thr kinases that phosphorylate key regulatory proteins involved in the control of cell differentiation, proliferation, chromosome segregation, circadian rhythms, and metabolic pathways. CK1 family members share a highly conserved kinase domain but differ in their variable N-and C-terminal domains. Mammals have seven family members: alpha, beta, gamma1, gamma2, gamma3, delta and epsilon. They all share at least 50% amino acid identity within the protein kinase catalytic domain. CK1 isoforms exclusively use ATP as phosphate donor and are generally co-factor independent. Casein kinase I epsilon is a Wnt-regulated kinase, and regulated phosphorylation of Dvl allows fine tuning of the Wnt-b-catenin signaling pathway. CKIe positively regulates Akt possibly by inhibiting PP2A. CKIe play an important role in neurodegenerative diseases.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|casein kinase 1 epsilon; CK1e; CKIe; RP1-5O6.1; HCKIE; MGC10398 ; CKI-epsilon; OTTHUMP00000063258; OTTHUMP00000063263; casein kinase 1 epsilon; casein kinase I epsilon|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Human recombit protein fragment corresponding to amino acids 153-416 of CSNK1E produced in E.coli|
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