CKIP-1 Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-2791	100 μL

Catalog No. 50-198-2791 Supplier Bioss Supplier No. BS1330R

Description

Rabbit Polyclonal Antibody

CKIP1 was identified through a yeast-two hybrid screening as a protein that would interact with only one of the two catalytic subunits of the casein kinase 2 complex. CKIP1 is a pleckstrin homology domain-containing protein localized within the nucleus and at the plasma membrane that interacts with CK2alpha but not CK2alpha′, and is thought to play a role in targeting CK2alpha to a particular cellular location. CKIP1 has been implicated in muscle differentiation and the regulation of cell morphology and actin cytoskeleton. CKIP1 can also interact with other proteins such as ATM, an upstream kinase of p53, and recruit the nuclear ATM to the plasma membrane, suggesting CKIP1 may regulate ATM function through re-localizing ATM. CKIP1 can also form a complex with the kinase AKT, leading to a down-regulation of PI3K/AKT signaling and suppression of tumor growth in vivo.

Specifications

• Antigen: CKIP-1
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: PLEKHO1
• Gene Accession No.: Q53GL0
• Gene Alias: 2810052M02Rik; BOS_2962; Casein kinase 2-interacting protein 1; C-Jun-binding protein; CK2 interacting protein 1; CK2 interacting protein 1; HQ0024c protein; CK2-interacting protein 1; CKIP1; CKIP-1; HQ0024c; HQ0024c protein; JBP; Jun zipper-associated 2; Jza2; JZA-20; LOC100152184; OC120; Osteoclast maturation-associated gene 120 protein; PH domain-containing family O member 1; pleckstrin homology domain containing O1; pleckstrin homology domain containing, family O member 1; Pleckstrin homology domain-containing family O member 1; pleckstrin homology domain-containing family O member 1-like; PLEKHO1; RGD1311487; RP11-458I7.3; TNF intracellular domain-interacting protein
• Gene Symbols: PLEKHO1
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human CKIP-1.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 51177
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG