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Invitrogen™ CLAC-P Polyclonal Antibody
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Catalog No. PIPA5101303
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100 μL
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PIPA5101303 100 μL
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Catalog No. PIPA5101303 Supplier Invitrogen™ Supplier No. PA5101303
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total Collagen XXV alpha 1.

Alzheimer's disease (AD) is characterized by deposition of beta-amyloid as senile plaques and cerebral amyloid angiopathy. The principal component of AD amyloid is the amyloid beta peptide (A beta). Although production and deposition of A beta appear closely related to the pathogenesis of AD, current evidence suggest that A beta alone is not sufficient to cause neuronal death and symptoms of dementia. A component of senile plaque (SP), CLAC (collagen-like Alzheimer amyloid plaque component ) and its precursor CLAC-P are deposited with extracellular beta-amyloid and have been recently implicated in cell toxicity of beta-amyloid in AD brains. CLAC-P is a unique, membrane-bound collagen-like structure containing three Gly-X-Y repeat motifs and may define a novel class of neuronal collagens.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CLAC-P
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene COL25A1
Gene Accession No. Q99MQ5, Q9BXS0
Gene Alias 2700062B08Rik; Alzheimer disease amyloid-associated protein; AMY; CFEOM5; CLAC; CLACP; CLAC-P; Col25a1; collagen alpha-1(XXV) chain; collagen type XXV alpha 1; collagen, type XXV, alpha 1; collagen-like Alzheimer amyloid plaque component; collagenous Alzheimer amyloid plaque component; procollagen, type XXV, alpha 1
Gene Symbols COL25A1
Host Species Rabbit
Immunogen A synthesized peptide derived from human COL25A1(Accession Q9BXS0), corresponding to amino acid residues Y102-K152.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 77018, 84570
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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