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Invitrogen™ CLAC-P Polyclonal Antibody

Catalog No. PIPA110881
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100 μg
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PIPA110881 100 μg
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Catalog No. PIPA110881 Supplier Invitrogen™ Supplier No. PA110881
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Description

Rabbit Polyclonal Antibody

PA1-10881 detects CLAC-P in human and mouse samples. PA1-10881 has been successfully used in Western blot and immunohistochemistry (paraffin embedded sections) procedures. A band of approximately 70 kDa is detected by Western blot in HEK293 cell lysate. PA1-10881 immunogen is a synthetic peptide corresponding to residues 430-445 of the NC3 region of human and mouse CLAC-P.

Alzheimer's disease (AD) is characterized by deposition of beta-amyloid as senile plaques and cerebral amyloid angiopathy. The principal component of AD amyloid is the amyloid beta peptide (A beta). Although production and deposition of A beta appear closely related to the pathogenesis of AD, current evidence suggest that A beta alone is not sufficient to cause neuronal death and symptoms of dementia. A component of senile plaque (SP), CLAC (collagen-like Alzheimer amyloid plaque component ) and its precursor CLAC-P are deposited with extracellular beta-amyloid and have been recently implicated in cell toxicity of beta-amyloid in AD brains. CLAC-P is a unique, membrane-bound collagen-like structure containing three Gly-X-Y repeat motifs and may define a novel class of neuronal collagens.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CLAC-P
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation PBS with no preservative; pH 7.4
Gene COL25A1
Gene Accession No. Q99MQ5, Q9BXS0
Gene Alias 2700062B08Rik; Alzheimer disease amyloid-associated protein; AMY; CFEOM5; CLAC; CLACP; CLAC-P; Col25a1; collagen alpha-1(XXV) chain; collagen type XXV alpha 1; collagen, type XXV, alpha 1; collagen-like Alzheimer amyloid plaque component; collagenous Alzheimer amyloid plaque component; procollagen, type XXV, alpha 1
Gene Symbols COL25A1
Host Species Rabbit
Immunogen Synthetic peptide corresponding to residues 430-445 of the NC3 region of human and mouse CLAC-P.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 77018, 84570
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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