Invitrogen™ CLASP2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5109547

Catalog No. PIPA5109547

Description

Immunogen sequence: NCTSKSVPVR RRSFEFLDLL LQEWQTHSLE RHAAVLVETI KKGIHDADAE ARVEARKTYM GLRNHFPGEA ETLYNSLEPS YQKSLQTYLK SSGSVASLPQ SDRSSSSSQE SLNRPFSSKW STANPSTVAG RVSAGSSKAS SLPGSLQRSR SDIDVNAAAG AKAHHAAGQS VRSGRLGAGA L.

CLASP2 is microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.

Specifications

• Antigen: CLASP2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Clasp2
• Gene Alias: 1500004F14Rik; 8030404L10Rik; C77448; CLASP2; CLASP2alpha; CLASP2beta; CLASP2gamma; CLIP associating protein 2; CLIP-associating protein 2; CLIP-associating protein CLASP2; cytoplasmic linker associated protein 2; cytoplasmic linker-associated protein 2; hOrbit2; Kiaa0627; mKIAA0627; multiple asters (Mast)-like homolog 2; protein Orbit homolog 2
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 114514, 23122, 76499
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.04 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O75122, Q8BRT1, Q99JD4
• Gene Symbols: Clasp2
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 220-400 of human CLASP2 (NP_001193973.1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov