Invitrogen™ Claudin 1 Polyclonal Antibody (MH25)

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ 717800

Catalog No. 71-780-0

Description

This antibody reacts with the ~ 22 kDa Claudin-1 protein. Reactivity was confirmed by western blotting and immunofluorescence. Positive controls include MDCK cells (dog), Caco-2cells (human), mouse liver, rat liver, and rat kidney. NOTE: This antibody strongly cross reacts with the Claudin-3 protein. It has been observed in western blotting inhibition studies using Caco-2 cell lysates, that this antibody is inhibited by addition of Claudin-3 peptide. For a Claudin-1 specific antibody that does not cross-react with Claudin-3, please order Cat. No. 519000 (Rb x Claudin-1) instead.

Claudin-1 is a member of the transmembrane protein family claudins located in cell-cell tight junctions and it acts as a co-receptor for HCV entry into hepatic cells. Claudins are abundant in luminal epithelial sheets where they maintain epithelial cell polarity. Claudin-1 is expressed in most tissues such as bladder, fallopian tube, liver, pancreas, prostate, and skin.

Specifications

• Antigen: Claudin 1
• Classification: Polyclonal
• Concentration: 0.25 mg/mL
• Formulation: PBS with 0.1% sodium azide; pH 7.4
• Gene Accession No.: O88551, O95832, P56745
• Gene Symbols: CLDN1
• Immunogen: A synthetic peptide derived from the C-terminus of the human/mouse Claudin-1 protein.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Canine
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Clone: MH25
• Conjugate: Unconjugated
• Gene: CLDN1
• Gene Alias: AI596271; claudin 1; claudin-1; CLD1; CLDN1; hypothetical protein; ILVASC; SEMP1; Senescence-associated epithelial membrane protein; senescence-associated epithelial membrane protein 1; tight junction protein; UNQ481/PRO944
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 12737, 608207, 65129, 9076
• Content And Storage: -20°C
• Form: Liquid