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Invitrogen™ Claudin 17 Monoclonal Antibody (410509)
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Catalog No. PIMA524150
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100 μg
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Catalog No. Quantity
PIMA524150 100 μg
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Catalog No. PIMA524150 Supplier Invitrogen™ Supplier No. MA524150
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Description

Mouse Monoclonal Antibody

This antibody stains human Claudin-17 transfectants but not irrelevant transfectants. Reconstitute at 0.5 mg/mL in sterile PBS.

Claudin 17 (CLDN17) is a member of the claudin family of proteins, characterized by their involvement in the formation of tight junctions, which are crucial for maintaining the selective permeability barrier in epithelial and endothelial cell layers. CLDN17 is located on chromosome 21q22.11 and encodes a transmembrane protein that contributes to paracellular permeability regulation. This protein is associated with facilitating the passage of ions and small molecules between cells, playing a vital role in maintaining cellular homeostasis and tissue integrity. Recent studies have implicated claudin 17 in tumorigenesis, particularly in hepatocellular carcinoma, where its overexpression is linked to a more malignant phenotype and poor prognosis through mechanisms such as the Tyk2/Stat3 signaling pathway. The dysregulation of claudin 17 and its role in cancer highlight its potential as a biomarker for diagnosis and prognosis, as well as a target for therapeutic interventions aimed at modulating tight junction integrity and cellular interactions in cancerous tissues.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Claudin 17
Applications Flow Cytometry
Classification Monoclonal
Clone 410509
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene CLDN17
Gene Accession No. P56750
Gene Alias claudin 17; claudin-17; CLDN17; human CLDN17 gene for claudin-17; MGC126552; MGC126554; UNQ758; UNQ758/PRO1489
Gene Symbols CLDN17
Host Species Mouse
Immunogen NS0 mouse myeloma cell line transfected with human Claudin-17 Met1-Val224.
Purification Method Protein A/G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26285
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG2b
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