Invitrogen™ Claudin 17 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA583800

Catalog No. PIPA583800

Description

Immunogen sequence: CNRKKQGYRY PVPGYRVPHT DKRRNTTMLS KTSTSYV.

Claudin 17 (CLDN17) is a member of the claudin family of proteins, characterized by their involvement in the formation of tight junctions, which are crucial for maintaining the selective permeability barrier in epithelial and endothelial cell layers. CLDN17 is located on chromosome 21q22.11 and encodes a transmembrane protein that contributes to paracellular permeability regulation. This protein is associated with facilitating the passage of ions and small molecules between cells, playing a vital role in maintaining cellular homeostasis and tissue integrity. Recent studies have implicated claudin 17 in tumorigenesis, particularly in hepatocellular carcinoma, where its overexpression is linked to a more malignant phenotype and poor prognosis through mechanisms such as the Tyk2/Stat3 signaling pathway. The dysregulation of claudin 17 and its role in cancer highlight its potential as a biomarker for diagnosis and prognosis, as well as a target for therapeutic interventions aimed at modulating tight junction integrity and cellular interactions in cancerous tissues.

Specifications

• Antigen: Claudin 17
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CLDN17
• Gene Alias: claudin 17; claudin-17; CLDN17; human CLDN17 gene for claudin-17; MGC126552; MGC126554; UNQ758; UNQ758/PRO1489
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 26285
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P56750
• Gene Symbols: CLDN17
• Immunogen: Recombinant protein corresponding to Human CLDN17. Recombinant protein control fragment (Product #RP-103829).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG