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Invitrogen™ Claudin 17 Polyclonal Antibody
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Catalog No. PIPA583800
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100 μL
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PIPA583800 100 μL
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Catalog No. PIPA583800 Supplier Invitrogen™ Supplier No. PA583800
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: CNRKKQGYRY PVPGYRVPHT DKRRNTTMLS KTSTSYV Highest antigen sequence indentity to the following orthologs: Rat - 59%, Mouse - 62%.

Claudin 17 (CLDN17) is a member of the claudin family of proteins, characterized by their involvement in the formation of tight junctions, which are crucial for maintaining the selective permeability barrier in epithelial and endothelial cell layers. CLDN17 is located on chromosome 21q22.11 and encodes a transmembrane protein that contributes to paracellular permeability regulation. This protein is associated with facilitating the passage of ions and small molecules between cells, playing a vital role in maintaining cellular homeostasis and tissue integrity. Recent studies have implicated claudin 17 in tumorigenesis, particularly in hepatocellular carcinoma, where its overexpression is linked to a more malignant phenotype and poor prognosis through mechanisms such as the Tyk2/Stat3 signaling pathway. The dysregulation of claudin 17 and its role in cancer highlight its potential as a biomarker for diagnosis and prognosis, as well as a target for therapeutic interventions aimed at modulating tight junction integrity and cellular interactions in cancerous tissues.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Claudin 17
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene CLDN17
Gene Accession No. P56750
Gene Alias claudin 17; claudin-17; CLDN17; human CLDN17 gene for claudin-17; MGC126552; MGC126554; UNQ758; UNQ758/PRO1489
Gene Symbols CLDN17
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human CLDN17. Recombinant protein control fragment (Product #RP-103829).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26285
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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