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Invitrogen™ Claudin 17 Polyclonal Antibody
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Catalog No. PIPA590256
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100 μL
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PIPA590256 100 μL
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Catalog No. PIPA590256 Supplier Invitrogen™ Supplier No. PA590256
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: CGMKQVQCTG SNERAKAYLL GTSGVLFILT GIFVLIPVSW TANIIIRDFY NPAIHIGQKR ELGAALFLGW ASAAVLFIGG GLLCGFCCCN RKKQGYRYPV PGYRVPHTDK RRNTTMLSKT STSYV; Positive Samples: Mouse kidney, Rat kidney; Cellular Location: Cell junction, Cell membrane, Multi-pass membrane protein, tight junction.

Claudin 17 (CLDN17) is a member of the claudin family of proteins, characterized by their involvement in the formation of tight junctions, which are crucial for maintaining the selective permeability barrier in epithelial and endothelial cell layers. CLDN17 is located on chromosome 21q22.11 and encodes a transmembrane protein that contributes to paracellular permeability regulation. This protein is associated with facilitating the passage of ions and small molecules between cells, playing a vital role in maintaining cellular homeostasis and tissue integrity. Recent studies have implicated claudin 17 in tumorigenesis, particularly in hepatocellular carcinoma, where its overexpression is linked to a more malignant phenotype and poor prognosis through mechanisms such as the Tyk2/Stat3 signaling pathway. The dysregulation of claudin 17 and its role in cancer highlight its potential as a biomarker for diagnosis and prognosis, as well as a target for therapeutic interventions aimed at modulating tight junction integrity and cellular interactions in cancerous tissues.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Claudin 17
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1.63 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene CLDN17
Gene Accession No. Q8BXA6
Gene Alias claudin 17; claudin-17; CLDN17; human CLDN17 gene for claudin-17; MGC126552; MGC126554; UNQ758; UNQ758/PRO1489
Gene Symbols CLDN17
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human CLDN17 (NP_0362631).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 239931, 304125
Target Species Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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