Invitrogen™ Claudin 17 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA590256

Catalog No. PIPA590256

Description

Immunogen sequence: CGMKQVQCTG SNERAKAYLL GTSGVLFILT GIFVLIPVSW TANIIIRDFY NPAIHIGQKR ELGAALFLGW ASAAVLFIGG GLLCGFCCCN RKKQGYRYPV PGYRVPHTDK RRNTTMLSKT STSYV; Positive Samples: Mouse kidney, Rat kidney; Cellular Location: Cell junction, Cell membrane, Multi-pass membrane protein, tight junction.

Claudin 17 (CLDN17) is a member of the claudin family of proteins, characterized by their involvement in the formation of tight junctions, which are crucial for maintaining the selective permeability barrier in epithelial and endothelial cell layers. CLDN17 is located on chromosome 21q22.11 and encodes a transmembrane protein that contributes to paracellular permeability regulation. This protein is associated with facilitating the passage of ions and small molecules between cells, playing a vital role in maintaining cellular homeostasis and tissue integrity. Recent studies have implicated claudin 17 in tumorigenesis, particularly in hepatocellular carcinoma, where its overexpression is linked to a more malignant phenotype and poor prognosis through mechanisms such as the Tyk2/Stat3 signaling pathway. The dysregulation of claudin 17 and its role in cancer highlight its potential as a biomarker for diagnosis and prognosis, as well as a target for therapeutic interventions aimed at modulating tight junction integrity and cellular interactions in cancerous tissues.

Specifications

• Antigen: Claudin 17
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CLDN17
• Gene Alias: claudin 17; claudin-17; CLDN17; human CLDN17 gene for claudin-17; MGC126552; MGC126554; UNQ758; UNQ758/PRO1489
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 239931, 304125
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1.63 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q8BXA6
• Gene Symbols: CLDN17
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human CLDN17 (NP_0362631).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse, Rat
• Product Type: Antibody
• Isotype: IgG