Invitrogen™ Claudin 18 Monoclonal Antibody (2F8)

Catalog No.	Quantity
FEMA550294	100 μL

Catalog No. FEMA550294 Supplier Invitrogen™ Supplier No. MA550294

Description

Mouse Monoclonal Antibody

Claudin 18 Monoclonal Antibody for IHC (P), ELISA

Claudin-18 is a tight junction protein expressed as lung-and stomach-specific isoforms which are generated by alternative splicing of the claudin-18 gene. The lung-specific form is a downstream target gene regulated by the T/EBP/NKX2.1 transcription factor. A splice variant lacking the C-terminal cytoplasmic domain also exists in mouse, but has not been confirmed in human. Human claudin-18 demonstrates 88% amino acid sequence identity to the mouse protein. Immunohistochemical studies have demonstrated complete membrane localization of claudin-18 in lung and stomach epithelial cells, while electron microscopy has shown that it is concentrated in the cell-cell borders of these cells. These features suggest a potentially important role for claudin-18 in the structure and function of tight junctions in the lung and stomach. Claudin-18 expression has also been reported in the inner ear.

Specifications

• Antigen: Claudin 18
• Applications: ELISA, Immunohistochemistry (Paraffin)
• Classification: Monoclonal
• Clone: 2F8
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.5% BSA, 50% glycerol and 0.02% sodium azide
• Gene: Cldn18
• Gene Accession No.: P56856
• Gene Alias: claudin 18; claudin 18-like; claudin-18; CLDN18; SFTA5; SFTPJ; surfactant associated 5; surfactant associated protein J; surfactant, pulmonary associated protein J; UNQ778/PRO1572
• Gene Symbols: Cldn18
• Host Species: Mouse
• Immunogen: Synthesized peptide derived from human Claudin 18.
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 51208
• Target Species: Human
• Content And Storage: -20°C or -80°C if preferred
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1 λ