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Invitrogen™ Claudin 18 Recombinant Human Monoclonal Antibody (25E3)
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Catalog No. FEMA549964
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100 μL
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FEMA549964 100 μL
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Catalog No. FEMA549964 Supplier Invitrogen™ Supplier No. MA549964
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Description

Human Recombinant Monoclonal Antibody

Claudin 18 Recombinant Monoclonal Antibody for Flow, ELISA

Claudin-18 is a tight junction protein expressed as lung-and stomach-specific isoforms which are generated by alternative splicing of the claudin-18 gene. The lung-specific form is a downstream target gene regulated by the T/EBP/NKX2.1 transcription factor. A splice variant lacking the C-terminal cytoplasmic domain also exists in mouse, but has not been confirmed in human. Human claudin-18 demonstrates 88% amino acid sequence identity to the mouse protein. Immunohistochemical studies have demonstrated complete membrane localization of claudin-18 in lung and stomach epithelial cells, while electron microscopy has shown that it is concentrated in the cell-cell borders of these cells. These features suggest a potentially important role for claudin-18 in the structure and function of tight junctions in the lung and stomach. Claudin-18 expression has also been reported in the inner ear.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Claudin 18
Applications ELISA, Flow Cytometry, Neutralization
Classification Recombinant Monoclonal
Clone 25E3
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.03% Proclin 300; pH 7.4
Gene Cldn18
Gene Accession No. P56856
Gene Alias claudin 18; claudin 18-like; claudin-18; CLDN18; SFTA5; SFTPJ; surfactant associated 5; surfactant associated protein J; surfactant, pulmonary associated protein J; UNQ778/PRO1572
Gene Symbols Cldn18
Host Species Human
Immunogen Recombinant Human CLDN18 protein.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 51208
Target Species Human
Content And Storage -20°C or -80°C if preferred
Product Type Antibody
Form Liquid
Isotype IgG1
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