Invitrogen™ Claudin 22/24 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5103747

Catalog No. PIPA5103747

Description

Antibody detects endogenous levels of total CLDN22/24.

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc. Alternatively spliced transcript variants encoding different isoforms have been found.

Specifications

• Antigen: Claudin 22/24
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CLDN24
• Gene Alias: claudin 21; claudin 22; claudin 24; Claudin-21; Claudin-22; CLDN21; CLDN22; CLDN24; Putative claudin-24
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 100132463, 306454, 502083, 53842
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: A6NM45, Q8N7P3
• Gene Symbols: CLDN22, CLDN24
• Immunogen: A synthesized peptide derived from human CLDN22(Accession Q8N7P3), corresponding to amino acid residues L125-S175.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat, Monkey
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov