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Claudin 4 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501984971
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50-198-4971 100 μL
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Catalog No. 50-198-4971 Supplier Bioss Supplier No. BS2790R
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Description

Rabbit Polyclonal Antibody

Claudin-4 belongs to the 20-member family of claudins, transmembrane cellular adhesion proteins localized at epithelial and endothelial tight junctions. Claudins demonstrate distinct, tissue-specific expression patterns, and are essential components of tight junction charge-specific channels that regulate paracellular ion flux. Claudin-4 is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. The overexpression of Claudin-4 has been shown to decrease paracellular electrical conductance due to a selective decrease in Na+ permeability, with no significant decrease in Cl- permeability. In ovarian carcinoma cells, Claudin-3 and Claudin-4 exhibit upregulation at both mRNA and protein levels. Claudin-4 is also overexpressed in pancreatic cancer tissues and cell lines, and in other epithelial cancers. The Claudin-4 gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems.

Specifications

Antigen Claudin 4
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene Cldn4
Gene Accession No. O14493
Gene Alias Cep-r; claudin 4; CLAUDIN4; Claudin-4; Cldn4; Clostridium perfringens enterotoxin receptor; Clostridium perfringens enterotoxin receptor 1; CPER; CPE-R; CPE-receptor; CPETR; CPETR1; h CPE-receptor; hCPE-R; WBSCR8; Williams-Beuren syndrome chromosomal region 8 protein
Gene Symbols Cldn4
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human CLDN4.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1364
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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