Invitrogen™ Claudin 5 Monoclonal Antibody (4C3C2), Alexa Fluor™ 488

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ 352588

Catalog No. 35-258-8

Description

Reactivity has been confirmed with rat, human and mouse Claudin-5 using rat lung, mouse kidney, mouse small intestine, mouse lung homogenates, human colon tissue, and CACO-2 human cell line. This antibody reacts specifically with the ~ 22-24 kDa endogenous Claudin-5 protein. Excitation/Peak Emission (nm): 495/519.

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc. Alternatively spliced transcript variants encoding different isoforms have been found.

Specifications

• Antigen: Claudin 5
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 4 mg/mL BSA and 0.1% sodium azide; pH 7.4
• Gene Accession No.: O00501, O54942, Q9JKD6
• Gene Symbols: CLDN5
• Immunogen: Synthetic peptide derived from the mouse Claudin-5 protein.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot, Immunocytochemistry
• Clone: 4C3C2
• Conjugate: Alexa Fluor 488
• Gene: CLDN5
• Gene Alias: AI854493; AWAL; BEC1; Brain endothelial cell clone 1 protein; claudin 5; claudin 5 (transmembrane protein deleted in velocardiofacial syndrome); claudin-5; claudin-5 protein; Cldn5; CPETRL1; lung-specific membrane protein; MBEC1; TMDVCF; TMVCF; Transmembrane protein deleted in VCFS; transmembrane protein deleted in velocardiofacial syndrome; Unknown (protein for MGC:138054)
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 12741, 65131, 7122
• Content And Storage: 4°C
• Form: Liquid
• Green Features: Responsibly packaged