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Invitrogen™ Claudin 5 Monoclonal Antibody (4C3C2), Alexa Fluor™ 488
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Catalog No. 352588
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Catalog No. Quantity
35-258-8 100 μg
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Catalog No. 35-258-8 Supplier Invitrogen™ Supplier No. 352588
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Description

Mouse Monoclonal Antibody

Reactivity has been confirmed with rat, human and mouse Claudin-5 using rat lung, mouse kidney, mouse small intestine, mouse lung homogenates, human colon tissue, and CACO-2 human cell line. This antibody reacts specifically with the ~ 22-24 kDa endogenous Claudin-5 protein. Excitation/Peak Emission (nm): 495/519.

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc. Alternatively spliced transcript variants encoding different isoforms have been found.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Claudin 5
Applications ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 4C3C2
Concentration 0.5 mg/mL
Conjugate Alexa Fluor 488
Formulation PBS with 4mg/mL BSA and 0.1% sodium azide; pH 7.4
Gene CLDN5
Gene Accession No. O00501, O54942, Q9JKD6
Gene Alias AI854493; AWAL; BEC1; Brain endothelial cell clone 1 protein; claudin 5; claudin 5 (transmembrane protein deleted in velocardiofacial syndrome); claudin-5; claudin-5 protein; Cldn5; CPETRL1; lung-specific membrane protein; MBEC1; TMDVCF; TMVCF; Transmembrane protein deleted in VCFS; transmembrane protein deleted in velocardiofacial syndrome; Unknown (protein for MGC:138054)
Gene Symbols CLDN5
Host Species Mouse
Immunogen Synthetic peptide derived from the mouse Claudin-5 protein.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12741, 65131, 7122
Target Species Human, Mouse, Rat
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG1
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