Invitrogen™ Claudin 6 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA599412

Catalog No. PIPA599412

Description

Antibody detects endogenous levels of total Claudin 6.

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.

Specifications

• Antigen: Claudin 6
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CLDN6
• Gene Alias: AL024037; claudin 6; Claudin6; claudin-6; CLD6; CLDN6; Skullin; tight junction molecule claudin 6; UNQ757/PRO1488
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 287098, 54419, 9074
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P56747, Q9Z262
• Gene Symbols: CLDN6
• Immunogen: A synthesized peptide derived from human CLDN6(Accession P56747), corresponding to amino acid residues L88-W138.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG