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Invitrogen™ CLCN1 Polyclonal Antibody
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Catalog No. PIPA537147
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100 μL
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PIPA537147 100 μL
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Catalog No. PIPA537147 Supplier Invitrogen™ Supplier No. PA537147
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Description

Rabbit Polyclonal Antibody

This antibody detects endogenous protein at a molecular weight of 110 kDa. Purity is >95% by SDS-PAGE.

The family of voltage-dependent chloride channels (CLCs) regulate cellular trafficking of chloride ions, a critical component of all living cells. CLCs regulate excitability in muscle and nerve cells, aid in organic solute transport and maintain cellular volume. CLC1 is highly expressed in skeletal muscle. Mutations in the gene encoding CLC1 lead to myotonia, an inheritable disorder characterized by muscle stiffness and renal salt wasting. CLC2 is highly expressed in the epithelia of several organs including lung, which suggests CLC2 may be a possible therapeutic target for cystic fibrosis. CLC3 expression is particularly abundant in neuronal tissue, while CLC4 expression is evident in skeletal and cardiac muscle as well as brain. Mutations in the gene encoding CLC5 lead to Dent's disease, a renal disorder characterized by proteinuria and hypercalciuria. CLC6 and CLC7 are broadly expressed in several tissues including testis, kidney, brain and muscle.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CLCN1
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene CLCN1
Gene Accession No. P35523, P35524, Q64347
Gene Alias adr; arrested development of righting response; chloride channel 1; chloride channel 1, skeletal muscle; chloride channel protein 1; Chloride channel protein, skeletal muscle; chloride channel, voltage-sensitive 1; chloride voltage-gated channel 1; CIC 1; CIC1; CLC1; Clc-1; Clcn1; MGC138361; MGC142055; mto; myotonia; nmf355; SMCC; SMCC1
Gene Symbols CLCN1
Host Species Rabbit
Immunogen A synthetic peptide corresponding to residues in human CLCN1.
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1180, 12723, 25688
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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