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Invitrogen™ CLCN3 Monoclonal Antibody (N258/5), PE
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Catalog No. PIMA545557
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100 μg
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Catalog No. Quantity
PIMA545557 100 μg
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Catalog No. PIMA545557 Supplier Invitrogen™ Supplier No. MA545557
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Description

Mouse Monoclonal Antibody

1 μg/mL of MA5-45557 was sufficient for detection of Clcn3 in 20 μg of rat brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 90kDa. Does not cross-react with Clcn4 or Clcn5 (based on KO validation results). This antibody was formerly sold as clone S258-5.

Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CLCN3
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone N258/5
Concentration 1 mg/mL
Conjugate PE
Formulation 2.48mM MES, 95.64mM phosphate with 0.5M EDTA and no preservative; pH 7.4
Gene CLCN3
Gene Accession No. P51790, P51791, P51792
Gene Alias chloride channel 3; chloride channel protein 3; chloride channel, voltage-sensitive 3; chloride transporter ClC-3; chloride voltage-gated channel 3; CIC3; Clc3; clC-3; CLCN 3; Clcn3; DKFZp564I0463; H(+)/Cl(-) exchange transporter 3; protein kinase C-regulated chloride channel
Gene Symbols CLCN3
Host Species Mouse
Immunogen Synthetic peptide amino acids 98-115 (cytoplasmic N-terminus) of rat Clcn3.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1182, 12725, 84360
Target Species Human, Mouse, Rat
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG1
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