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Invitrogen™ CLCNKA Polyclonal Antibody
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Catalog No. PIPA5101518
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100 μL
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PIPA5101518 100 μL
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Catalog No. PIPA5101518 Supplier Invitrogen™ Supplier No. PA5101518
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total CLCNKA.

CLC-KA is a kidney-specific chloride channel that mediates transepithelial chloride transport in the thin ascending limb of the Henle loop in the inner medulla. CLC-KA plays a crucial role in urine concentration. The gene encoding human CLC-KA maps to chromosome 1p36. Mutations in this gene may be associated with nephrogenic diabetes insipidus in those cases where mutations in the vasopressin V2 receptor and the AQP2 water channel are lacking. CLC-KB mediates basolateral chloride ion efflux in the thick ascending limb and in more distal nephron segments. The gene encoding human CLC-KB maps to chromosome 1p36. Mutations in this gene cause type III Barter's syndrome which is characterized by renal salt-wasting and low blood pressure.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CLCNKA
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene CLCNKA
Gene Accession No. P51800
Gene Alias C75963; chloride channel K1; chloride channel Ka; Chloride channel protein ClC-Ka; chloride channel, kidney, A; chloride channel, voltage-sensitive Ka; chloride voltage-gated channel Ka; CLCK1; clC-K1; CLCKA; CLC-KA; Clcnk1; Clcnka; hClC-Ka; putative basolateral cTAL chloride channel ClC-Ka
Gene Symbols CLCNKA
Host Species Rabbit
Immunogen A synthesized peptide derived from human CLCNKA(Accession P51800), corresponding to amino acid residues E583-L633.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1187
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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