Invitrogen™ CLCNKA Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA563472

Catalog No. PIPA563472

Description

Immunogen sequence: IVKKLPYLPR ILGRNIGSHH VRVEHFMNHS ITTLA Highest antigen sequence identity to the following orthologs: Mouse - 74%, Rat - 74%.

CLC-KA is a kidney-specific chloride channel that mediates transepithelial chloride transport in the thin ascending limb of the Henle loop in the inner medulla. CLC-KA plays a crucial role in urine concentration. The gene encoding human CLC-KA maps to chromosome 1p36. Mutations in this gene may be associated with nephrogenic diabetes insipidus in those cases where mutations in the vasopressin V2 receptor and the AQP2 water channel are lacking. CLC-KB mediates basolateral chloride ion efflux in the thick ascending limb and in more distal nephron segments. The gene encoding human CLC-KB maps to chromosome 1p36. Mutations in this gene cause type III Barter's syndrome which is characterized by renal salt-wasting and low blood pressure.

Specifications

• Antigen: CLCNKA
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CLCNKA
• Gene Alias: C75963; chloride channel K1; chloride channel Ka; Chloride channel protein ClC-Ka; chloride channel, kidney, A; chloride channel, voltage-sensitive Ka; chloride voltage-gated channel Ka; CLCK1; clC-K1; CLCKA; CLC-KA; Clcnk1; Clcnka; hClC-Ka; putative basolateral cTAL chloride channel ClC-Ka
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1187
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P51800
• Gene Symbols: CLCNKA
• Immunogen: Recombinant protein corresponding to Human CLCNKA. Recombinant protein control fragment (Product #RP-104514).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov