CLCNKA Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Catalog No.	Quantity
50-172-9423	150 μL

Catalog No. 50-172-9423 Supplier Proteintech Group Inc Supplier No. 144021AP150UL

Description

Rabbit Polyclonal Antibody

CLC-KA is a kidney-specific chloride channel that mediates transepithelial chloride transport in the thin ascending limb of the Henle loop in the inner medulla. CLC-KA plays a crucial role in urine concentration. The gene encoding human CLC-KA maps to chromosome 1p36. Mutations in this gene may be associated with nephrogenic diabetes insipidus in those cases where mutations in the vasopressin V2 receptor and the AQP2 water channel are lacking. CLC-KB mediates basolateral chloride ion efflux in the thick ascending limb and in more distal nephron segments. The gene encoding human CLC-KB maps to chromosome 1p36. Mutations in this gene cause type III Barter′s syndrome which is characterized by renal salt-wasting and low blood pressure.

Specifications

• Antigen: CLCNKA
• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Classification: Polyclonal
• Concentration: 0.24 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: CLCNKA
• Gene Accession No.: P51800, Q06393, Q9WUB7
• Gene Alias: chloride channel Ka, ClC K1, CLCK1, CLCNKA, hClC Ka
• Gene Symbols: Clcnka
• Host Species: Rabbit
• Immunogen: CLCNKA Fusion Protein Ag5647
• Purification Method: Antigen Affinity Chromatography
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1187, 12733, 79425
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG