CLDN16 Rabbit anti-Canine, Human, Polyclonal, Proteintech

Catalog No.	Quantity
50-173-5724	150 μL

Catalog No. 50-173-5724 Supplier Proteintech Group Inc Supplier No. 276381AP150UL

Description

Rabbit Polyclonal Antibody

Tight junction group of proteins are a cell-to-cell adhesion structure in epithelial cells that constitute the epithelial junctional complex with adherens junctions and desmosomes. Tight junction strands are mainly composed of claudins, occludin, and JAM. Claudin-16 belongs to the Claudin family of protein which is composed of 23 integral membrane proteins. Claudins are responsible for the formation of tight junction strands and are connected with the actin cytoskeleton mediated by ZO-1. Claudin 16, also known as Paracellin-1, is a renal tight junction protein required for paracellular magnesium resorption. It is localized in the intercellular junctions of the epithelial cells of the thick ascending limb of Henle′s loop (a TAL marker) are used to localize this specific structure of nephrons in kidney sections. Mg2+ resorption occurs in TAL, and Claudin-16 is required for this paracellular function. Failure in renal ′handling′ of magnesium can result in hypermagnesemia, whose major direct toxicity implications are cardiovascular as well as renal failure. Recent studies have shown that the lack of Claudin-16 proteins contributes to the dysfunction of paracellular renal transport systems.

Specifications

• Antigen: CLDN16
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 0.2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene: CLDN16
• Gene Accession No.: Q9Y5I7
• Gene Alias: claudin 16, CLDN16, HOMG3, Paracellin 1, PCLN 1, PCLN1
• Gene Symbols: CLDN16
• Host Species: Rabbit
• Immunogen: CLDN16 Fusion Protein Ag26531
• Purification Method: Antigen Affinity Chromatography
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 10686, 608218
• Target Species: Canine, Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG