CLEC10A/CD301 Antibody (ER-MP23) - BSA Free, Novus Biologicals™

Rat Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
NB017659	Novus Biologicals NB100648740.025MG	0.025 mg
NB10064874	Novus Biologicals NB10064874	0.125 mg

Description

CLEC10A/CD301 Monoclonal specifically detects CLEC10A/CD301 in Mouse samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Frozen.

Specifications

• Antigen: CLEC10A/CD301
• Concentration: 1.0 mg/mL
• Applications: Immunofluorescence, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry
• Conjugate: Unconjugated
• Host Species: Rat
• Target Species: Mouse
• Gene ID (Entrez): 10462
• Immunogen: Balb/c macrophage precursor cell hybrids
• Primary or Secondary: Primary
• Content And Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

• Clone: ER-MP23
• Dilution: Flow Cytometry, Immunohistochemistry 1:10-1:500, Immunocytochemistry/Immunofluorescence 1:10-1:500, Immunohistochemistry-Frozen 1:10-1:500
• Classification: Monoclonal
• Form: Purified
• Regulatory Status: RUO
• Gene Alias: CD301 antigen, CD301C-type lectin domain family 10 member A, CLECSF13, CLECSF14macrophage C-type lectin, C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamilymember 14 (macrophage-derived), C-type lectin domain family 10, member A, C-type lectin superfamily member 14, HML2, HMLC-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamilymember 13 (macrophage-derived), Macrophage lectin 2, macrophage lectin 2 (calcium dependent), MGL
• Gene Symbols: CLEC10A
• Isotype: IgG2a
• Purification Method: Protein G purified
• Test Specificity: NB100-64874 recognizes murine CD301, a 38 kD cell surface protein that is otherwise known as macrophage galactose N-acetylgalactosamine lectin (MGL) or dendritic cell asialoglycoprotein (DC-ASGPR). In mice, CD301 is predominantly expressed on mature macrophages found associated with a wide range of connective tissues including macrophages in the dermis and the pancreas. Clone ER-MP23 also detects a population of dendritic cells in lymphoid tissue, which are probably recent immigrants from peripheral connective tissue sites. Expression of CD301 is induced by alternative (i.e. IL-4/IL-13 mediated) activation of macrophages and dendritic cells, but not all CD301 positive cells are necessarily IL-4/IL-13 stimulated. Clone ER-MP23 is reported to block the function of mouse CD301. The antibody binds both MGL1 and MGL2 homologues.

For Research Use Only