Invitrogen™ CLIC5 Polyclonal Antibody

Catalog No.	Quantity
PIPA5119978	100 μL

Catalog No. PIPA5119978 Supplier Invitrogen™ Supplier No. PA5119978

Description

Rabbit Polyclonal Antibody

Positive Control: Human lung tissue lysates, mouse small intestine tissue. Subcellular Location: Cytoplasm, cytoskeleton, apical cell membrane, cell cortex, membrane; centrosome, golgi apparatus.

Clic5 encodes a protein that is required for normal hearing and is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti. Clic5 can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Clic5 may play a role in the regulation of transepithelial ion absorption and secretion, and is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture. The Clic5 gene encodes a member of the chloride intracellular channel (CLIC) family of chloride ion channels. The protein encoded by Clic5 associates with actin-based cytoskeletal structures and may also play a role in multiple processes including hair cell stereocilia formation, myoblast proliferation and glomerular podocyte and endothelial cell maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for the Clic5 gene. Diseases associated with CLIC5 include Deafness, Autosomal Recessive 103 and Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb.

Specifications

• Antigen: CLIC5
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: TBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
• Gene: CLIC5
• Gene Accession No.: Q8BXK9, Q9NZA1
• Gene Alias: 5730531E12Rik; B330005L24; chloride channel protein; chloride channel protein p64; chloride intracellular channel 5; chloride intracellular channel protein 5; Chlorine channel protein p64; CLIC5; DFNB102; DFNB103; Gm322; jbg; MST130; MSTP130
• Gene Symbols: CLIC5
• Host Species: Rabbit
• Immunogen: Recombinant protein within human CLIC5 aa 41-240.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 224796, 53405
• Target Species: Human, Mouse
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG