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Invitrogen™ CLIP1 Polyclonal Antibody
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Catalog No. PIPA519167
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100 μg
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PIPA519167 100 μg
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Catalog No. PIPA519167 Supplier Invitrogen™ Supplier No. PA519167
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Description

Goat Polyclonal Antibody

This antibody is predicted to react with canine, mouse, porcine and rat based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 8,000.

CLIP170 was initially identified as a new type of intermediate filament associated protein that is highly expressed in Reed-Sternberg cells, the tumoral cells diagnostic for Hodgkin's disease. Later experiments showed that it is located at microtubule plus ends and is required for the binding of endocytic carrier vesicles. CLIP170 has also been suggested to act with LIS1, a protein implicated in brain development, to regulate dynein/dynactin binding microtubules. Other studies suggest that CLIP170 can influence the formation of lamellipodia and cell invasion by invasive breast cancer cells by regulating the release of kinesin and IQGAP1 from a complex of those proteins, CLIP170 and Rac1. At least two isoforms of CLIP170 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CLIP1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene CLIP1
Gene Accession No. P30622
Gene Alias 1110007I12Rik; 4631429H07Rik; AV017631; C81039; CAP-Gly domain containing linker protein 1; CAP-Gly domain-containing linker protein 1; CLIP; Clip 170; Clip1; CLIP170; CLIP-170; Clip50; Cyln1; cytoplasmic linker protein 1; Cytoplasmic linker protein 170; Cytoplasmic linker protein 170 alpha-2; cytoplasmic linker protein 50; cytoplasmic linker protein CLIP-170; Kiaa4046; MGC131604; mKIAA4046; Reed-Steinberg cell-espressed intermediate filament-associated protein; Reed-Sternberg intermediate filament-associated protein; Restin; restin (Reed-Steinberg cell-espressed intermediate filament-associated protein); restin (Reed-Steinberg cell-expressed intermediate filament-associated protein); Rsn
Gene Symbols CLIP1
Host Species Goat
Immunogen Synthetic peptide sequence (PHSTHHGSRGEERP) corresponding to the C-terminus amino acids of CLIP1 (aa 1404-1418).
Purification Method Ammonium sulfate precipitation
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6249
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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