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CLIP170 Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Catalog No. 501564898
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50-156-4898 100 μL
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Catalog No. 50-156-4898 Supplier Bethyl Laboratories, Inc Supplier No. A303345A
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections. Based on 100% sequence identity, this antibody is predicted to react with Mouse

CLIP170 was initially identified as a new type of intermediate filament associated protein that is highly expressed in Reed-Sternberg cells, the tumoral cells diagnostic for Hodgkin′s disease. Later experiments showed that it is located at microtubule plus ends and is required for the binding of endocytic carrier vesicles. CLIP170 has also been suggested to act with LIS1, a protein implicated in brain development, to regulate dynein/dynactin binding microtubules. Other studies suggest that CLIP170 can influence the formation of lamellipodia and cell invasion by invasive breast cancer cells by regulating the release of kinesin and IQGAP1 from a complex of those proteins, CLIP170 and Rac1. At least two isoforms of CLIP170 are known to exist.

Specifications

Antigen CLIP170
Applications Immunohistochemistry, Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 1 mg/ml
Conjugate Unconjugated
Formulation phosphate, tris citrate with 0.09% sodium azide; pH 7-8
Gene CLIP1
Gene Accession No. P30622
Gene Alias CLIP1; CAP-GLY domain containing linker protein 1; CLIP; CLIP-170; CLIP170; CYLN1; MGC131604; RSN; Reed-Steinberg cell-expressed intermediate filament-associated protein; cytoplasmic linker 1; restin; restin (Reed-Steinberg cell-expressed intermediate filament-associated protein)
Gene Symbols CLIP1
Host Species Rabbit
Immunogen Between 1388 and 1438
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6249
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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