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Invitrogen™ CLN2 Polyclonal Antibody
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Catalog No. PIPA596372
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100 μL
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PIPA596372 100 μL
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Catalog No. PIPA596372 Supplier Invitrogen™ Supplier No. PA596372
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: GANISTWVYS SPGRHEGQEP FLQWLMLLSN ESALPHVHTV SYGDDEDSLS SAYIQRVNTE LMKAAARGLT LLFASGDSGA GCWSVSGRHQ FRPTFPASSP YVTTVGGTSF QEPFLITNEI VDYISGGGFS NVFPRPSYQE EAVTKFLSSS PHLPPSSYFN ASGRAYPDVA ALSDGYWVVS NRVPIPWVSG TSASTPVFGG ILSLINEHRI LSGRPPLGFL NPRLYQQHGA GLFDVTRGCH ESCLDEEVEG QGFCSGPGWD PVTGWGTPNF PALLKTLLNP; Positive Samples: BT-474, SW480; Cellular Location: Lysosome, Melanosome.

This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CLN2
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.67 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene TPP1
Gene Accession No. O14773, O89023
Gene Alias cell growth-inhibiting gene 1 protein; ceroid-lipofuscinosis, neuronal 2; CLN 2; CLN2; GIG 1; GIG1; growth-inhibiting protein 1; LPIC; lysosomal pepstatin insensitive protease; lysosomal pepstatin-insensitive protease; MGC21297; SCAR7; TPP 1; TPP I; Tpp1; TPP-1; TPPI; TPP-I; Tripeptidyl aminopeptidase; tripeptidyl peptidase 1; tripeptidyl peptidase I; tripeptidyl peptidase-I; tripeptidyl-peptidase 1; Tripeptidyl-peptidase I; UNQ267/PRO304
Gene Symbols TPP1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 284-563 of human TPP1 (NP_0003823).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1200, 12751
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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