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CLN6, Mouse anti-Human, Clone: N400/24 , Millipore Sigma™

Catalog No. MABN2548100 Shop All MilliporeSigma Products
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MABN2548100 100 μg
MABN254825 25 μg
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Catalog No. MABN2548100 Supplier MilliporeSigma Supplier No. MABN2548100UG
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Description

Mouse Monoclonal Antibody

Anti-CLN6, clone N400/24, Cat. No. MABN2548, is a highly specific mouse monoclonal antibody that targets CLN6 and has been tested for use in Immunohistochemistry (Paraffin).

Ceroid-lipofuscinosis neuronal protein 6 (UniProt: Q9NWW5; also known as CLN6) is encoded by the CLN6 gene (Gene ID: 54982) in human. CLN6 is a multi-pass membrane protein that is localized to endoplasmic reticulum and contributes to lysosomal function and viability of neurons. It has no homology with known proteins or functional domains, however it is highly conserved across mammalian species. Mutations in CLN6 gene have been linked to ceroid lipofuscinosis, neuronal 6 and 4A that are characterized by intracellular accumulation of autofluorescent liposomal material, seizures, dementia, visual loss, and/or cerebral atrophy. Two isoforms of CLN6 have been described that are produced by alternative splicing.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CLN6
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone N400/24
Conjugate Unconjugated
Formulation Purified mouse monoclonal antibody IgG2b in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Alias Ceroid-lipofuscinosis neuronal protein 6
Gene Symbols CLN6
Host Species Mouse
Immunogen Recombinant fragments corresponding to 54, 47, and 30 amino acids from non-helical regions from the N-terminal, internal, and C-terminal regions of human Ceroid-lipofuscinosis neuronal protein 6 (CLN6).
Purification Method Protein G purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Neuroscience
Primary or Secondary Primary
Gene ID (Entrez) NP_060352.1
Test Specificity Clone N400/24 specifically detects human Ceroid-lipofuscinosis neuronal protein 6. It does not cross-react with other CLN proteins.
Target Species Human
Content And Storage Stable for 1 year at 2-8°C from date of receipt.
Form Purified
Isotype IgG2b κ
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