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  5. Tocris Bioscience™ CLP 257

Tocris Bioscience™ CLP 257
GREENER_CHOICE

Catalog No. 524250
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Selective KCC2 activator

CLP 257 is a selective KCC2 K+-Cl- cotransporter activator (EC50 = 616 nM). Exhibits selectivity for KCC2 over other KCC family members, NKCC1 and GABAA receptors, as well as 55 other receptors. Enhances Cl- transport and increases KCC2 plasma membrane expression in spinal slices with reduced KCC2 function. Alleviates hypersensitivity in rats with peripheral nerve injury.

Specifications

Chemical Name or Material (5Z)-5-[(4-Fluoro-2-hydroxyphenyl)methylene]-2-(tetrahydro-1-(2H)-pyridazinyl)-4(5H)-thiazolone
CAS 1181081-71-9
Quantity 50 mg
Target KCC2 Activators
Molecular Formula C14H14FN3O2S
Formula Weight 307.34
Purity >98%
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