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Invitrogen™ CLSTN1 Polyclonal Antibody
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Catalog No. PIPA5102984
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100 μL
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PIPA5102984 100 μL
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Catalog No. PIPA5102984 Supplier Invitrogen™ Supplier No. PA5102984
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total CLSTN1.

CLSTN1 induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, CLSTN1 stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, CLSTN1 abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding.CLSTN1 may modulate calcium-mediated postsynaptic signals.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CLSTN1
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene CLSTN1
Gene Accession No. O94985, Q9EPL2
Gene Alias 1810034E21Rik; alcadein alpha; alcadein-alpha; alc-alpha; alcalpha1; alcalpha2; Alzheimer-related cadherin-like protein; cadherin-related family member 12; calsyntenin 1; calsyntenin-1; CDHR12; CLSTN1; clstn1 protein; CS1; CST-1; CSTN1; C-terminal fragment 1-alpha; CTF1-alpha; FLJ32258; fm67g03; Kiaa0911; Non-classical cadherin XB31alpha; PIK3CD; SAlc-alpha; Soluble Alc-alpha; wu:fk52g02; wu:fm67g03; XB31alpha; zgc:153744; zgc:56528
Gene Symbols CLSTN1
Host Species Rabbit
Immunogen A synthesized peptide derived from human CLSTN1(Accession O94985), corresponding to amino acid residues T895-I945.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22883, 65945
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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