Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. PIPA542599

Invitrogen™ CLSTN1 Polyclonal Antibody
GREENER_CHOICE

Catalog No. PIPA542599
Change view
Click to view available options
Quantity:
100 μL
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
PIPA542599 100 μL
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. PIPA542599 Supplier Invitrogen™ Supplier No. PA542599
Add to Cart
Add to Cart

Description

Rabbit Polyclonal Antibody

Peptide sequence: KPWLEPTYHG IVTENDNTVL LDPPLIALDK DAPLRFAESF EVTVTKEGEI Sequence homology: Cow: 82%; Dog: 92%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 85%.

CLSTN1 induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, CLSTN1 stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, CLSTN1 abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding.CLSTN1 may modulate calcium-mediated postsynaptic signals.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CLSTN1
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene CLSTN1
Gene Accession No. O94985
Gene Alias 1810034E21Rik; alcadein alpha; alcadein-alpha; alc-alpha; alcalpha1; alcalpha2; Alzheimer-related cadherin-like protein; cadherin-related family member 12; calsyntenin 1; calsyntenin-1; CDHR12; CLSTN1; clstn1 protein; CS1; CST-1; CSTN1; C-terminal fragment 1-alpha; CTF1-alpha; FLJ32258; fm67g03; Kiaa0911; Non-classical cadherin XB31alpha; PIK3CD; SAlc-alpha; Soluble Alc-alpha; wu:fk52g02; wu:fm67g03; XB31alpha; zgc:153744; zgc:56528
Gene Symbols CLSTN1
Host Species Rabbit
Immunogen Synthetic peptide directed towards the N-terminal of human CLSTN1 (aa 35-84).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22883
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
Show More Show Less
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.