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Invitrogen™ CLSTN1 Polyclonal Antibody
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Catalog No. PIPA552936
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100 μL
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PIPA552936 100 μL
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Catalog No. PIPA552936 Supplier Invitrogen™ Supplier No. PA552936
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: SHEPFSVTED YPLHPSKIET QLVVGACWQE FSGVENDNET EPVTVASAGG DLHMTQFFRG NLAGLTLRSG KLADKKVIDC LYTCKEGLDL QVLEDSGRGV QIQAHPSQLV LTLEGEDLGE LDKAMQHISY LNS Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 77%.

CLSTN1 induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, CLSTN1 stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, CLSTN1 abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding.CLSTN1 may modulate calcium-mediated postsynaptic signals.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CLSTN1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene CLSTN1
Gene Accession No. O94985
Gene Alias 1810034E21Rik; alcadein alpha; alcadein-alpha; alc-alpha; alcalpha1; alcalpha2; Alzheimer-related cadherin-like protein; cadherin-related family member 12; calsyntenin 1; calsyntenin-1; CDHR12; CLSTN1; clstn1 protein; CS1; CST-1; CSTN1; C-terminal fragment 1-alpha; CTF1-alpha; FLJ32258; fm67g03; Kiaa0911; Non-classical cadherin XB31alpha; PIK3CD; SAlc-alpha; Soluble Alc-alpha; wu:fk52g02; wu:fm67g03; XB31alpha; zgc:153744; zgc:56528
Gene Symbols CLSTN1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human CLSTN1. Recombinant protein control fragment (Product #RP-90471).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22883
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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