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Invitrogen™ CLSTN1 Polyclonal Antibody
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Catalog No. PIPA5109556
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100 μL
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PIPA5109556 100 μL
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Catalog No. PIPA5109556 Supplier Invitrogen™ Supplier No. PA5109556
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: ARVNKHKPWL EPTYHGIVTE NDNTVLLDPP LIALDKDAPL RFAGEICGFK IHGQNVPFDA VVVDKSTGEG VIRSKEKLDC ELQKDYSFTI QAYDCGKGPD GTNVKKSHKA TVHIQVNDVN EYAPVFKEKS YKATVIEGKQ YDSILRVEAV DADCSPQFSQ ICSYEIITPD VPFTVDKDGY IKNTEKLNYG KEHQYKLTVT AYDCGKKRAT EDVLVKISIK PTCTPGWQGW NNRIEYEPGT GALAVFPNIH LETCDEPVAS VQATVELETS HIGKGCDRDT YSEKSLHRLC GAAAGTAELL PSPSGSLNWT MGLPTDNGHD SD.

CLSTN1 induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, CLSTN1 stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, CLSTN1 abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding.CLSTN1 may modulate calcium-mediated postsynaptic signals.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CLSTN1
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 2.04 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene CLSTN1
Gene Accession No. Q6Q0N0, Q9EPL2
Gene Alias 1810034E21Rik; alcadein alpha; alcadein-alpha; alc-alpha; alcalpha1; alcalpha2; Alzheimer-related cadherin-like protein; cadherin-related family member 12; calsyntenin 1; calsyntenin-1; CDHR12; CLSTN1; clstn1 protein; CS1; CST-1; CSTN1; C-terminal fragment 1-alpha; CTF1-alpha; FLJ32258; fm67g03; Kiaa0911; Non-classical cadherin XB31alpha; PIK3CD; SAlc-alpha; Soluble Alc-alpha; wu:fk52g02; wu:fm67g03; XB31alpha; zgc:153744; zgc:56528
Gene Symbols CLSTN1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 29-350 of human CLSTN1 (NP_055759.3).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 313717, 65945
Target Species Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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