Invitrogen™ CMG2 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA547422

Catalog No. PIPA547422

Description

In direct ELISAs and Western blots, approximately 20% cross-reactivity with recombinant mouse CMG-2 is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

Anthrax toxin receptor 2 (ATR2), also designated capillary morphogenesis gene 2 (CMG2), is a cellular receptor for anthrax toxin. ATR2/CMG2 is a type 1 membrane protein that includes an extracellular von Willebrand factor A (VWA) domain with a metal ion-dependent adhesion site (MIDAS) motif. ATR2/CMG2 binds to protective antigen (PA) which is one of the three monomeric proteins which are released as anthrax toxin from Bacillus anthracis. Once bound, PA facilitates the delivery of the other two proteins, edema factor (EF) and lethal factor (LF), into the cytosol. Mutations in the gene ATR2/CMG2 result in inhibition of binding by the vWA domain, associated with infantile systemic hyalinosis (ISH) and juvenile hyaline fibromatosis (JHF). ISH and JHF are rare stiff-skin syndromes characterized by hyaline desposition in various organs, especially the skin and gingiva.

Specifications

• Antigen: CMG2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ANTXR2
• Gene Alias: 2310046B19Rik; anthrax toxin receptor 2; ANTXR cell adhesion molecule 2; ANTXR cell adhesion molecule 2; anthrax toxin receptor 2; ANTXR2; AW561899; Capillary morphogenesis gene 2 protein; capillary morphogenesis protein 2; cI-35; CMG2; CMG-2; FLJ31074; HFS; ISH; JHF; MGC111533; MGC45856
• Host Species: Goat
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 118429
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: ELISA, Flow Cytometry, Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: P58335
• Gene Symbols: ANTXR2
• Immunogen: Mouse myeloma cell line NS0-derived recombinant human CMG-2/ANTXR2 isoform 1 Gln34-Asn317.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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