Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. PIPA547422

Invitrogen™ CMG2 Polyclonal Antibody
GREENER_CHOICE

Catalog No. PIPA547422
Change view
Click to view available options
Quantity:
100 μg
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
PIPA547422 100 μg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. PIPA547422 Supplier Invitrogen™ Supplier No. PA547422
Add to Cart
Add to Cart

Description

Goat Polyclonal Antibody

In direct ELISAs and Western blots, approximately 20% cross-reactivity with recombinant mouse CMG-2 is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

Anthrax toxin receptor 2 (ATR2), also designated capillary morphogenesis gene 2 (CMG2), is a cellular receptor for anthrax toxin. ATR2/CMG2 is a type 1 membrane protein that includes an extracellular von Willebrand factor A (VWA) domain with a metal ion-dependent adhesion site (MIDAS) motif. ATR2/CMG2 binds to protective antigen (PA) which is one of the three monomeric proteins which are released as anthrax toxin from Bacillus anthracis. Once bound, PA facilitates the delivery of the other two proteins, edema factor (EF) and lethal factor (LF), into the cytosol. Mutations in the gene ATR2/CMG2 result in inhibition of binding by the vWA domain, associated with infantile systemic hyalinosis (ISH) and juvenile hyaline fibromatosis (JHF). ISH and JHF are rare stiff-skin syndromes characterized by hyaline desposition in various organs, especially the skin and gingiva.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CMG2
Applications ELISA, Flow Cytometry, Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene ANTXR2
Gene Accession No. P58335
Gene Alias 2310046B19Rik; anthrax toxin receptor 2; ANTXR cell adhesion molecule 2; ANTXR cell adhesion molecule 2; anthrax toxin receptor 2; ANTXR2; AW561899; Capillary morphogenesis gene 2 protein; capillary morphogenesis protein 2; cI-35; CMG2; CMG-2; FLJ31074; HFS; ISH; JHF; MGC111533; MGC45856
Gene Symbols ANTXR2
Host Species Goat
Immunogen Mouse myeloma cell line NS0-derived recombinant human CMG-2/ANTXR2 isoform 1 Gln34-Asn317.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 118429
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG
Show More Show Less

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.