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Invitrogen™ CMG2 Polyclonal Antibody
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Catalog No. PIPA5117052
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100 μL
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PIPA5117052 100 μL
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Catalog No. PIPA5117052 Supplier Invitrogen™ Supplier No. PA5117052
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Description

Rabbit Polyclonal Antibody

Positive Samples: Mouse eye, Rat lung Immunogen sequence: QEQPSCRRAF DLYFVLDKSG SVANNWIEIY NFVQQLAERF VSPEMRLSFI VFSSQATIIL PLTGDRGKIS KGLEDLKRVS PVGETYIHEG LKLANEQIQK AGGLKTSSII IALTDGKLDG LVPSYAEKEA KISRSLGASV YCVGVLDFEQ AQLERIADSK EQVFPVKGGF QALKGIINSI LAQSCTEILE LQPSSVCVGE EFQIVLSGRG FMLGSRNGSV LCTYTVNETY TTSVKPVSVQ LNSMLCPAPI LNKAGETLDV SVSFNGG.

Anthrax toxin receptor 2 (ATR2), also designated capillary morphogenesis gene 2 (CMG2), is a cellular receptor for anthrax toxin. ATR2/CMG2 is a type 1 membrane protein that includes an extracellular von Willebrand factor A (VWA) domain with a metal ion-dependent adhesion site (MIDAS) motif. ATR2/CMG2 binds to protective antigen (PA) which is one of the three monomeric proteins which are released as anthrax toxin from Bacillus anthracis. Once bound, PA facilitates the delivery of the other two proteins, edema factor (EF) and lethal factor (LF), into the cytosol. Mutations in the gene ATR2/CMG2 result in inhibition of binding by the vWA domain, associated with infantile systemic hyalinosis (ISH) and juvenile hyaline fibromatosis (JHF). ISH and JHF are rare stiff-skin syndromes characterized by hyaline desposition in various organs, especially the skin and gingiva.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CMG2
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.89 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
Gene ANTXR2
Gene Accession No. P58335, Q6DFX2
Gene Alias 2310046B19Rik; anthrax toxin receptor 2; ANTXR cell adhesion molecule 2; ANTXR cell adhesion molecule 2; anthrax toxin receptor 2; ANTXR2; AW561899; Capillary morphogenesis gene 2 protein; capillary morphogenesis protein 2; cI-35; CMG2; CMG-2; FLJ31074; HFS; ISH; JHF; MGC111533; MGC45856
Gene Symbols ANTXR2
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 34-300 of human ANTXR2 (NP_0011392661).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 118429, 305633, 71914
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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