Tocris Bioscience™ CMPD101

Description

Potent and selective GRK2/3 inhibitor

CMPD101 is a potent and selective GRK2/3 inhibitor (IC50 values are 32 and 54 nM for GRK3 and GRK2, respectively). Exhibits selectivity for GRK2/3 over GRK1/5. Reduces DAMGO -induced desensitization and internalization of μ-opioid receptors.

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Specifications

• Chemical Name or Material: 3-[[[4-Methyl-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]methyl]amino]-N-[[2-(trifluoromethyl)phenyl]methyl]benzamide
• CAS: 865608-11-3
• Quantity: 10 mg
• Target: G Protein (Heterotrimeric) Inhibitors
• Molecular Formula: C₂₄H₂₁F₃N₆O
• Formula Weight: 466.46
• Purity: >98%