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Tocris Bioscience™ CMPI hydrochloride
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Catalog No. 596310
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10 mg
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Catalog No. Quantity
59-631-0 10 mg
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Catalog No. 59-631-0 Supplier Tocris Bioscience™ Supplier No. 5963/10
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Description

Potent positive allosteric modulator of α4β2 nAChRs; also inhibitor of (α4)2(β2)3, muscle-type and Torpedo nAChRs

Potent positive allosteric modulator of α4β2 nAChRs (EC50 values are 20 and 18 nM for rat and human, respectively). Selective for hα4β2 over hα3β2, hα3β4 and hα7. Inhibits (α4)2(β2)3, muscle-type and Torpedo nAChRs (IC50 values are 0.5, 0.7 and 0.2 μM, respectively), but not (α4)3(β2)2 receptors. Exhibits ability to photoincorporate into aliphatic and nucleophilic amino acid side chains.

Chemical Identifiers

CAS 2250025-94-4

Specifications

Quantity 10 mg
Solubility Soluble to 50mM in water and to 100mM in DMSO
Formula Weight 379.28
Physical Form Solid
Purity >98%
Chemical Name or Material 3-(2-Chlorophenyl)-5-(5-methyl-1-(piperidin-4-yl)-1H-pyrazol-4-yl)isoxazole hydrochloride

Safety and Handling

Recommended Storage Store at -20°C
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