Invitrogen™ CNGB1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5101543

Catalog No. PIPA5101543

Description

Antibody detects endogenous levels of total CNGB1.

Glutamic acid rich protein (GARP) is a soluble protein localized to the outer segments of the rod photoreceptor. GARPs are characterized by six repeated motifs of: V V E K K N/E E. These repeat motifs help form an alpha-helix structure. The function(s) of GARP have not been fully characterized, but studies have suggested that GARP helps limit cGMP turnover by inhibiting phosphodiesterase activity. To date, there have been two splice variants characterized: GARP1 (full-length GARP) and GARP2 (truncated GARP). GARP also interacts with part of the larger cytoplasmic domain of the beta-subunit of the cyclic GMP-gated channel found in the plasma membrane.

Specifications

• Antigen: CNGB1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CNGB1
• Gene Alias: 240 kDa protein of rod photoreceptor CNG-channel; 240K protein of rod photoreceptor cng-channel; CNCG2; CNCG3L; CNCG4; cng channel; CNG channel 4; CNG channel beta-1; CNG4; CNG-4; CNG4c protein; CNGB1; CNGB1B; cyclic nucleotide gated channel beta 1; cyclic nucleotide gated channel subunit beta 1; cyclic nucleotide-gated cation channel 4; Cyclic nucleotide-gated cation channel beta-1; cyclic nucleotide-gated cation channel gamma; Cyclic nucleotide-gated cation channel modulatory subunit; cyclic nucleotide-gated channel beta subunit 1; cyclic nucleotide-gated channel beta subunit 1c; cyclic nucleotide-gated channel beta subunit 1d; cyclic nucleotide-gated channel beta subunit 1e; cyclic nucleotide-gated channel beta-1; GAR1; GARP; GARP2; glutamic acid-rich protein; glutamic-acid-rich protein; Gm1959; RCNC2; RCNCb; RCNCbeta; RP45; splice variant; tGARP; glutamic acid rich protein; truncated rod photoreceptor cGMP-gated channel beta-subunit
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1258, 333329, 83686
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q14028
• Gene Symbols: CNGB1
• Immunogen: A synthesized peptide derived from human CNGB1(Accession Q14028), corresponding to amino acid residues V917-D967.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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