CNIH2/CNIH3 (extracellular) Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA5111788

Catalog No. PIPA5111788

Description

Reconstitute antibody with 50 μL of double distilled water (DDW). The reconstituted solution can be stored at 4 degrees C for up to 1 week. For longer periods, small aliquots should be stored at -20 degrees C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min). Peptide sequence is: RARERLKNIE RIC Homology: CNIH2 : Mouse, human identical.CNIH3 : Rat, mouse, human - 11/13 amino acid residues identical.

Cornichon homologs (CNIHs) are a family of AMPA-type glutamate receptor (AMPAR) auxiliary subunits that modulate AMPAR ion channel function and trafficking. Cornichon 2 and 3 (CNIH2/3) are responsible for controlling the export of AMPARs from the endoplasmic reticulum and associate with synaptic AMPARs to modulate channel kinetics. CNIHs are small proteins with three transmembrane domains that directly binds to AMPARs. Overexpression CNIHs and AMPA receptors causes their localization to the Golgi apparatus. CNIH and TARP both compete for the bindingto AMPAR subunitsGluA2,GluA3, andGluA4subunits suggesting both proteins bind to the same site. CNIH2/3 binding to AMPARs is dependent on AMPAR subunit composition and TARPs.

Specifications

• Antigen: CNIH2/CNIH3 (extracellular)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Cnih2
• Gene Alias: 2900075G08Rik; Cnih2; CNIH-2; Cnih3; CNIH-3; Cnil; Cornichon family AMPA receptor auxiliary protein 2; Cornichon family AMPA receptor auxiliary protein 3; Cornichon-like protein; Protein cornichon homolog 2; Protein cornichon homolog 3; RGD1304930
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 12794, 361705, 690252, 72978
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: Western Blot
• Concentration: 0.8 mg/mL
• Formulation: PBS with 1% BSA and 0.05% sodium azide; pH 7.4
• Gene Accession No.: D0Q0Y7, O35089, Q5BJU5, Q6ZWS4
• Gene Symbols: Cnih2, Cnih3
• Immunogen: Peptide corresponding to amino acid residues 49-61 of rat CNIH2 (Extracellular loop)
• Quantity: 50 μL
• Primary or Secondary: Primary
• Target Species: Mouse, Rat
• Product Type: Antibody
• Isotype: IgG