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Invitrogen™ CNNM3 Polyclonal Antibody
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Catalog No. PIPA553478
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PIPA553478 100 μL
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Catalog No. PIPA553478 Supplier Invitrogen™ Supplier No. PA553478
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: FTYYGVSALT VPSSVHQSPV SSLQPIRHDL QPDPGDGTHS SAYCPDYTVR ALSDLQLIKV TRLQYLNALL ATRAQNLPQS PENTDLQVIP GSQTRLLGEK TTTA Highest antigen sequence identity to the following orthologs: Mouse - 81%, Rat - 81%.

CNNM3, also known as cyclin M3, is part of the CNNM family of proteins that play a critical role in magnesium ion transport across cellular membranes. This gene is notably expressed in the proximal tubule of the kidney, and its protein product localizes to the lateral membrane, suggesting its involvement in magnesium homeostasis. The structural analysis of the CNNM3 protein reveals it contains a cyclic nucleotide-binding homology domain with a characteristic beta-roll structure capped by an α-helical bundle, which is typical of cyclic nucleotide-binding domains. CNNM proteins were originally discovered in bacteria and are conserved across various organisms, indicating their fundamental biological importance. CNNM3 has been studied for its ability to decrease whole cellular magnesium content and free intracellular magnesium activity when expressed in model systems such as Xenopus laevis oocytes.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CNNM3
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene CNNM3
Gene Accession No. Q8NE01
Gene Alias Acdp3; ancient conserved domain protein 3; ancient conserved domain-containing protein 3; Clp3; Cnnm3; cyclin and CBS domain divalent metal cation transport mediator 3; cyclin M3; cyclin-M3; mACDP3; metal transporter CNNM3
Gene Symbols CNNM3
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human CNNM3. Recombinant protein control fragment (Product #RP-91095).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26505
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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