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Invitrogen™ CNOT1 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA561253
Description
Immunogen sequence: TIETLMRINA HSRGNAPEGL PQLMEVVRSN YEAMIDRAHG GPNFMMHSGI SQASEYDDPP GLREKAEYLL REWVNLYHSA AAGRDSTKAF SAFVG Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES) cell identity. [UniProt].
Specifications
CNOT1 | |
Polyclonal | |
Unconjugated | |
CNOT1 | |
6030411K04Rik; AA815922; AD-005; adrenal gland protein AD-005; CCR4-associated factor 1; CCR4-NOT transcription complex subunit 1; CCR4-NOT transcription complex, subunit 1; CDC39; Cnot1; D830048B13; Kiaa1007; Negative regulator of transcription subunit 1 homolog; NOT1; NOT1 (negative regulator of transcription 1, yeast) homolog; NOT1H; RGD1308009 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
23019 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunohistochemistry (Paraffin) | |
0.5 mg/mL | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
A5YKK6 | |
CNOT1 | |
Recombinant protein corresponding to Human CNOT1. Recombinant protein control fragment (Product #RP-95506). | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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