Invitrogen™ CNOT1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA561253

Catalog No. PIPA561253

Description

Immunogen sequence: TIETLMRINA HSRGNAPEGL PQLMEVVRSN YEAMIDRAHG GPNFMMHSGI SQASEYDDPP GLREKAEYLL REWVNLYHSA AAGRDSTKAF SAFVG Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.

Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES) cell identity. [UniProt].

Specifications

• Antigen: CNOT1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CNOT1
• Gene Alias: 6030411K04Rik; AA815922; AD-005; adrenal gland protein AD-005; CCR4-associated factor 1; CCR4-NOT transcription complex subunit 1; CCR4-NOT transcription complex, subunit 1; CDC39; Cnot1; D830048B13; Kiaa1007; Negative regulator of transcription subunit 1 homolog; NOT1; NOT1 (negative regulator of transcription 1, yeast) homolog; NOT1H; RGD1308009
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23019
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.5 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: A5YKK6
• Gene Symbols: CNOT1
• Immunogen: Recombinant protein corresponding to Human CNOT1. Recombinant protein control fragment (Product #RP-95506).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov