Invitrogen™ CNOT2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA566949

Catalog No. PIPA566949

Description

Immunogen sequence: DGSENVTGLDL SDFPALADRN RREGSGNPTP LINPLAGRAP YVGMVTKPAN EQSQDFSIHN EDFPALPGSS YKDPT Highest antigen sequence identity to the following orthologs - mouse 100%, rat 100%.

CCR4-NOT Transcription Complex 2 (CNOT2) is a component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. CNOT2 is required for the CCR4-NOT complex structural integrity. It can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. CNOT2 is involved in the maintenance of embryonic stem (ES) cell identity. (UniProt).

Specifications

• Antigen: CNOT2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Cnot2
• Gene Alias: 2600016M12Rik; 2810470K03Rik; AA537049; AA959607; AW557563; C79650; CCR4-associated factor 2; CCR4-NOT transcription complex subunit 2; CCR4-NOT transcription complex, subunit 2; CDC36; CNOT2; HSPC131; MSTP046; negative regulator of transcription 2; NOT2; NOT2H
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4848
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.6 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9NZN8
• Gene Symbols: Cnot2
• Immunogen: Recombinant Human CNOT2. Recombinant protein control fragment (Product #RP-105435).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG