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Invitrogen™ CNOT4 Polyclonal Antibody
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Catalog No. PIPA5101501
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PIPA5101501 100 μL
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Catalog No. PIPA5101501 Supplier Invitrogen™ Supplier No. PA5101501
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total CNOT4.

CNOT4 is a 575 amino acid protein with E3 ubiquitin ligase activity, mainly involved in protein modification and protein ubiquitination. It contains a ring type zinc finger domain of the C4C4 type, an RNA recognition motif and a bipartite nuclear localization signal.Studies show that CNOT4 is a component of the CCR4-NOT (CAF1) core complex that functions as general transcription regulation complex and has both a positive as well as a negative effect on the transcription of multiple functionally unrelated genes, thus controls gene expression. CNOT4 interacts with CNOT1 via C-terminus and with E2 ubiquitin ligases via C4C4 RING domain. Reports suggest that CNOT4 gets phosphorylated in response to DNA damage on consensus sites recognized by ATM and ATR.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CNOT4
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene CNOT4
Gene Accession No. O95628, Q8BT14
Gene Alias CCR4-associated factor 4; CCR4-NOT transcription complex subunit 4; CCR4-NOT transcription complex subunit 4 L homeolog; CCR4-NOT transcription complex subunit 4 S homeolog; CCR4-NOT transcription complex subunit 4 S homeolog; CCR4-NOT transcription complex, subunit 4; CCR4-NOT transcription complex, subunit 4 isoform a; CLONE243; cnot4; cnot4.S; E3 ubiquitin-protein ligase CNOT4; hypothetical protein; negative regulator of transcription 4; Not4; NOT4 (negative regulator of transcription 4, yeast) homolog; Not4h; Not4hp; Potential transcriptional repressor NOT4Hp; RING-type E3 ubiquitin transferase CNOT4; transcriptional repressor NOT4Hp; XELAEV_18019807mg
Gene Symbols CNOT4
Host Species Rabbit
Immunogen A synthesized peptide derived from human CNOT4(Accession O95628), corresponding to amino acid residues E62-F112.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 312227, 4850, 53621
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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