Invitrogen™ CNOT6 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5100444

Catalog No. PIPA5100444

Description

Antibody detects endogenous levels of total CNOT6.

Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Mediates cell proliferation and cell survival and prevents cellular senescence.

Specifications

• Antigen: CNOT6
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CNOT6
• Gene Alias: carbon catabolite repression 4 protein; carbon catabolite repressor protein 4 homolog; Ccr4; CCR4 carbon catabolite repression 4-like; Ccr4a; CCR4-NOT transcription complex subunit 6; CCR4-NOT transcription complex, subunit 6; Cnot6; Cytoplasmic deadenylase; Kiaa1194; LOW QUALITY PROTEIN: CCR4-NOT transcription complex subunit 6; RGD1310783
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 104625, 287249, 57472
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q6AXU9, Q8K3P5, Q9ULM6
• Gene Symbols: CNOT6
• Immunogen: A synthesized peptide derived from human CNOT6(Accession Q9ULM6), corresponding to amino acid residues Y495-L545.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov