Invitrogen™ CNOT6L Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA525131

Catalog No. PIPA525131

Description

This antibody is predicted to react with mouse and Xenopus based on sequence homology.

Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA. Its mRNA deadenylase activity can be inhibited by TOB1. Mediates cell proliferation and cell survival and prevents cellular senescence. [UniProt].

Specifications

• Antigen: CNOT6L
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CNOT6L
• Gene Alias: Carbon catabolite repressor protein 4 homolog B; CCR4b; CCR4-NOT transcription complex subunit 6 like; CCR4-NOT transcription complex subunit 6-like; CCR4-NOT transcription complex, subunit 6-like; CNOT6L
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography, Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 246175
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene Accession No.: Q96LI5
• Gene Symbols: CNOT6L
• Immunogen: KLH conjugated synthetic peptide between 414-442 amino acids from the C-terminal region of human CNO6L.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov